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Influence of low molecular weight heparin combined with low dose aspirin for treating women with recurrent spontaneous abortion on their coagulation indexes levels and Th17/Treg cytokines ratio |
| 1.The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, 325200；2.The Second Affiliated Hospital of Wenzhou Medical University |
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Abstract To investigate the influence of low molecular weight heparin combined with low dose aspirin for treating women with recurrent spontaneous abortion (RSA) on their coagulation indexes levels and Th17/Treg cytokines ratio. Methods: 112 women with RSA were selected and divided into two groups (56 cases in each group) according to random number table from January 2018 to December 2019. The women in the control group were given routine treatment, and the women in the observation group were given low molecular weight heparin combined with low dose aspirin except to routine treatment. The effect of women was compared between the two groups, and the serum coagulation indexes and Th17/Treg cytokine levels of the women in the two groups were determined before and after treatment. Results: The success rate of fetus preservation of the women in the observation group was 92.9%, which was significant higher than that (78.6%) of the women in the control group (P<0.05). After treatment, there were no significant differences in platelet count (PLT), and the levels of fibrinogen (FIB), activated partial prothrombin time (APTT), and tissue-type plasminogen activator (t-PA) of the women between the two groups (P>0.05). The levels of D-dimer, plasminogen activation inhibitor-1 (PAI-1) and Th17 cells, Th17/Treg ratio, interleukin-17 (IL-17), interleukin-6 (IL-6) and the IL-17/IL-10 ratio of the women in the observation group were significant lower than those of the women in the control group, but the levels of Treg cells, transforming growth factor-β (TGF-β), and interleukin-10 (IL-10) of the women in the observation group were significant higher (P<0.05). There were no significant differences in the incidence of adverse drug reactions and complications rate during pregnancy of the women between the two groups (P>0.05). Conclusion: Low molecular weight heparin combined with low dose aspirin can adjust the prethrombotic state and Th17/Treg cytokine ratio of women with RSA, so it can improve the effect of fetal protection without affecting their coagulation function.
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