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| The value of serum high mobility group protein, soluble CD40L, placental growth factor, and soluble vascular growth factor receptor-1 levels of the pregnant women for predicting their preeclampsia |
| 1.Zhongshan Hospital Affiliate to Xiamen University, Xiamen, Fujian Province, 361004；2. Zhongshan Hospital of Fudan University (Xiamen Branch) |
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Abstract To investigate the values of the serum high mobility group protein（HMGB1), soluble CD40L（sCD40L), placental growth factor（PIGF), and soluble vascular growth factor receptor-1（sFlt-1) levels of the pregnant women for predicting their preeclampsia (PE). Methods: 92 pregnant women with PE were selected in study group and were divided into group A (50 women with mild PE) and group B (42 women with severe PE) according to the severity of PE from January 2019 to December 2020. 50 normal pregnant women were selected in control group during the same period. The levels of the serum HMGB1, sCD40L, PIGF, and sFlt-1 of the women in the three groups were measured by enzyme-linked immunoassay（ELISA). Receiver operating characteristic curve (ROC) was used to analyze the value of the levels of serum HMGB1, sCD40L, PIGF, and sFlt-1 for diagnosing and predicting PE. Results: The values of 24 h urinary protein, systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP), and the levels of serum HMGB1, sCD40L, and SFLT-1 of the women in the study group were significantly higher than those of the women in the control group, but the serum PIGF level of the women in the study group was significantly lower. The variation range of the values of 24 h urinary protein, SBP, DBP, and MAP, and the levels of serum HMGB1, sCD40L, and SFLT-1 of the women in group B was significantly higher than those of the women in group A (all P＜0.05). ROC curve analysis had showed than the best value of ROC, the sensitivity, and the specificity of the combined the serum HMGB1, sCD40L, PIGF, and sFlt-1 levels for diagnosing PE were 0.810, 81.0%, and 82.1%, respectively. Conclusion: The levels of serum HMGB1, sCD40L, PIGF, sFlt-1 of the pregnant women are closely related to their occurrence of PE and their increased blood pressure. The combined detections of the serum HMGB1, sCD40L, PIGF, and sFlt-1 levels can predicate the occurrence and outcomes of the pregnant women with PE, which can provide reference basis for clinical diagnosis of PE.
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