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Abstract To investigate the relationship between the levels of serum interleukin-17 (IL-17), β-HCG, estradiol (E2) and progesterone (P) of the pregnant women during the first trimester of pregnancy and their pregnancy outcomes. Methods: The clinical data of 590 pregnant women during the first trimester of pregnancy from August 2019 to February 2021 were collected and were divided into group A (369 women with normal pregnancy outcomes) and group B (221 women with adverse pregnancy outcomes) according to their pregnancy outcomes. Chemiluminescence method was used to detect the levels of serum IL-17, E2, P and β-HCG of the women in the two groups. Results: There were 380 (66.4%) women with one or multiple of the levels of IL-17, E2, P, and βHCG, which included 13.2% women with abnormal IL-17 level only, 12.5% women with abnormal E2 level only, 13.4% women with abnormal P level only, and 12.2% women with abnormal β-HCG level only. There were 13.1% women with ≥2 abnormality of the levels of IL-17, E2, P, and β-HCG. The incidence of the adverse pregnancy outcomes of the pregnant women with the abnormal increase of the IL-17 and β-HCG levels, and the abnormal decrease of E2 and P levels had increased significantly (P＜0.05). Conclusion: The probability of adverse pregnancy outcomes of the pregnant women with the abnormal levels of serum IL-17, E2, P, and β-HCG during the first trimester of pregnancy increases, which should be paid attention in clinic.
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