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| Value of the combined detections of serum alpha-fetoprotein, human chorionic gonadotropin, free estriol, and inhibin-A of pregnant women during the second trimester of pregnancy for predicting their adverse pregnancy outcomes |
| The 904th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Wuxi, Jiangsu Province, 214000 |
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Abstract To explore the combined detections of serum alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), free estriol (uE3) and inhibin-A of pregnant women during the second trimester of pregnancy for predicting their adverse pregnancy outcomes. Methods: The clinical data of 600 primiparae from January 2017 to December 2019 were analyzed retrospectively. The levels of serum AFP, β-hCG, uE3, and inhibin-A of these primiparae during the second trimester of pregnancy were detected, and which efficiency for predicting the adverse pregnancy outcomes of these primiparae was evaluated. Results: Among 600 pregnant women, there were 34 (5.7%) cases with adverse pregnancy, and 21 (3.5%) cases with adverse perinatal infant outcomes. The serum levels of AFP, β-HCG, and Inhibin-A of the women with adverse pregnancy outcomes had increased significantly, and their uE3 level had decreased significantly (P＜0.05). The area under the curve of the combined serum AFP, β-HCG, uE3, and Inhibin-A levels for predicting the adverse maternal outcomes or the adverse perinatal infant outcomes was 0.902 or 0.854, which had no statistical significant different from that of the postpartum results (P＞0.05). Conclusion: The combined serum AFP, β-HCG, uE3, and Inhibin-A of the singleton primiparas during the second trimester of pregnancy for predicting their adverse pregnancy outcomes has better predictive effect.
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