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Abstract To explore the expression level of serum anti-Müllerian hormone (AMH) of the women with different subtypes of polycystic ovary syndrome (PCOS), and to study its correlation with the glucose and lipid metabolism indexes of the women. Methods: The clinical data of 184 women with PCOS from February 2020 to February 2021 were analyzed retrospectively. These women were included in study group, and were divided into group A (39 cases with anovulatory or sparse ovulation（OA) and polycystic ovary (PCO)), group B (50 cases with clinical manifestations of OA and high androgen, such as hirsutism and acne, and/or hyperandrogenism（HA)), group C (51 cases with OA, PCO, and HA), and group D (44 cases with PCO and HA). 58 healthy women were selected in control group. The general data, the levels of serum AMH, the glucose metabolism index, such as the levels of fasting insulin (FINS) and fasting blood glucose (FPG), and the resistance index (HOMA-IR) value, and the differences of lipid metabolism levels, such as triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), of the women were compared among these groups. Person correlation analysis was used to analyze the correlation between the AMH level of the women and their various indicators. Results: The serum AMH level of the women in group A, group B, group C, or group D was significantly higher than that of the women in the control group, while the levels of FBG and FINS, and the HOMA-IR value of the women in group D were significantly higher than those of the women in group A, B, and C, the levels of lipid metabolism indexes, such as TC and TG of the women in group C were significantly higher than those of the women in group A, group B, group D, or the control group. The LDL-C level of the women in group D was significantly higher than that of the women in group B, group D, or the control group (all P<0.05). The serum AMH level of the women with PCOS was moderately correlated with their glucose and lipid metabolism indexes levels (r=0.565, 0.514, 0.483, 0.470, and 0.523), and which was weakly correlated with their TC and LDL-C levels (r=0.338, 0.328) (all P<0.05). Conclusion: The serum AMH level of the women with PCOS elevates abnormally, which is related to their glucose and lipid metabolism indexes. The women with different types of PCOS have different degrees of abnormal glucose and lipid metabolism, so understanding the changes of the glucose and lipid metabolism indexes of the women with PCOS is helpful for targeted treatment.
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