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Abstract To investigate the changes of serum fetal liver kinase（Flk)-1 and cyclooxygenase-2（COX-2) levels of women with endometriosis（EMs), and to study their correlation with the degree of pain and the EMs condition of the women. Methods: A total of 112 women with EMs were selected in study group between January 2019 to December 2020, and which were further divided into group A (23 women with painless), group B (26 women with mild pain), group C (45 women with moderate pain), and group D (18 women with severe pain) according to the degree of pelvic pain by Visual Analog Scale（VAS), and which were also further divided into group E (16 women with stage I of EMs ), group F (44 women with stage II of EMs), group G (29 women with stage III of EMs), and group H (23 women with stage IV of EMs) according to the EMs condition by the American Fertility Association's revised staging method (r-AFS). 70 healthy women of childbearing age were selected in control group. The serum levels of Flk-1 and COX-2 of the women in these group were detected, and their correlation with the degree of pain of the women were analyzed. Results: The levels of serum FLK-1 (26.60±7.44ng/ml) and COX-2 (3.16±0.53ng/ml) of the women in the study group were significantly higher than those (6.52±1.13ng/ml and 1.42±0.31ng/ml) of the women in the control group (P<0.05). The levels of Flk-1 and COX-2 of the women in the study group had increased with their increasing VAS score and R-AFS stage (P<0.05). Linear correlation analysis showed that serum FLK-1 level of the women was positively correlated with their serum COX-2 level, and the levels of Flk-1 and COX-2 of the women were positively correlated with their VAS score and R-AFS stage (R =0.781, 0.658, 0.792, and 0.708, P<0.05). Conclusion: The women with EMs have obvious high expressions of the serum Flk-1 and COX-2, which are closely related to their EMs stage and their degree of pain, which can provide reference for clinical evaluation and treatment of EMs.
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