To explore the molecular mechanism of Kangfu Gel for treating Cervical HPV Infection based on network pharmacology and molecular docking. Methods: TCMSP and BATMAN databases were used to search the chemical composition and targets of Kangfu gel. Cervical HPV infection-related targets were searched and integrated by using OMIM, GeneCards, and DisGeNET databases. The co-targets of Kangfu gel and the disease were obtained by Venn analysis and protein-protein interaction (PPI), gene ontology (GO) function, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway for enrichment analysis. The interaction network diagram of “components-targets-pathways” was constructed by Cytoscape software. Moreover, the Autodock vina software was used to molecularly dock small molecules and core receptor macromolecules. Results: A total of 91 active compounds related to Kangfu gel were screened. 239 targets were related to cervical HPV infection, which potentially regulated 126 signal pathways including signal pathways of PI3K-Akt, HIF-1, FoxO and TNF. The molecular docking results showed that the top 5 core targets of TP53, AKT1, STAT3, HSP90AA1, and EGFR had good binding ability with the corresponding active ingredients. Conclusion: Kangfu gel for treating cervical HPV infection has the characteristics of multi-target, multi-channel, and multi-molecule compatibility. This research provided ideas of further researches on the mechanism and clinical effect of Kangfu gel for treating cervical HPV infection.