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| Serum placental growth factor and pregnancy associated plasma protein A levels, and the mean arterial pressure value of pregnant women during the first trimester of pregnancy for predicting preeclampsia occurrence |
| 1. Haining Maternal and Child Health Care Hospital, Zhejiang Province, 314000; 2. Affiliated Obstetrics and Gynecology Hospital of Zhejiang University |
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Abstract To analyze the value of the levels of serum placental growth factor (PLGF) and pregnancy associated plasma protein A (PAPP-A), and the mean arterial pressure (MAP) of pregnant women during the first trimester of pregnancy for predicting preeclampsia (PE) occurrence. Methods: Pregnant women during the first trimester of pregnancy were selected as the research subjects from January 2019 to October 2020. The serum PLGF and PAPP-A of these women were detected by enzyme linked immunosorbent assay (ELISA), their MAP value was measured, and their pregnancy outcomes were followed up. According to PE occurrence, these women were divided into 85 cases with PE in group A and 170 cases without PE in group B. The women in group A were further divided into group A1 (21 cases with severe PE) and group A2 (64 cases with mild PE group), or group A3 (18 cases with early onset PE) and group A4 (67 cases with late onset PE). Results: The levels of serum PlGF and PAPP-A of the women in group A were significantly lower than those of the women in group B, and the MAP value of the women in group A was significantly higher (P＜0.001). The levels of serum PlGF and PAPP-A of the women in group A1 were significantly lower than those of the women in group A2, and the levels of serum PlGF and PAPP-A of the women in group A3 were significantly lower than those of the women in group A4 (P＜0.05), and there was no significant difference in the MAP value of the women between group A1 and group A2, and between group A3 and group A4. The levels of serum PlGF and PAPP-A, and the MAP value had predictive efficacy for PE, and the efficacy, the sensitivity, and the specificity of the combined of the levels of serum PlGF and PAPP-A, and the MAP value for predicting PE were significantly higher than those of the serum PlGF level, the serum PAPP-A level, or the MAP value alone (P＜0.05). The levels of serum PlGF and PAPP-A had predictive efficacy for severe PE or late onset PE, and AUC, the sensitivity, and the specificity of the combined of the levels of serum PlGF and PAPP-A for predicting severe PE or late onset PE were significantly higher than those of the serum PlGF level or the serum PAPP-A level alone (P＜0.05). The MAP value of the women had no predictive efficacy for severe PE or late onset PE (P＞0.05). Conclusion: The combined of the levels of serum PlGF and PAPP-A, and the MAP value of the pregnant women during the first trimester of pregnancy has better predictive efficiency for their preeclampsia occurrence and the preeclampsia type.
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