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Abstract To investigate the relationship between the levels of serum malondialdehyde(MDA) and chemokine of women with gestational diabetes mellitus(GDM) and their perinatal outcomes. Methods: 108 women with GDM(in study group) and 108 healthy pregnancy women(in control group) from January 2017 to August 2020 were analyzed retrospectively. The levels of MDA and chemokine of the women in the two groups were detected. The women in the study were further divided into group A(women with adverse outcomes) and group B(women without adverse outcomes) according to their perinatal outcomes. The risk factors of adverse perinatal outcomes were analyzed. Results: The levels of MDA, chemokine, FBG, and IRI of the women in the two groups had increased with the increase of their gestational weeks, and those of the women in the study group were significant higher than those of the women in the control group(P<0.05). The incidence(60.2%) of total adverse perinatal outcomes, such as cesarean section, macrosomia, neonatal hypoglycemia, preterm delivery, and gestational hypertension of the women in the study group was significant higher than that(18.5%) of the women in the control group. In the study group, the levels of MDA, chemokine, FBG, and IRI of the women in group A were significantly higher than those of the women in group B(P<0.05). The increase of MDA, chemokine, and IRI levels of the women with GDM were the independent influencing factors of the adverse pregnancy outcomes(P<0.05). Conclusion: The women with GDM have obvious oxidative stress reaction, and their abnormal up-regulation of serum MDA and the chemokine levels increase the risk of cesarean section, macrosomia, neonatal hypoglycemia, premature delivery, and gestational hypertension, which are all the high-risk factors of adverse perinatal outcomes.
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