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| Correlation between the level of serum inflammatory factors of pregnant women with gestational diabetes mellitus and their levels of hepatocyte growth factor and adipocytokines |
| Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University, Xuzhou, Jiangsu Province, 221000 |
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Abstract To explore the relationship between the level of serum inflammatory factors of pregnant women with gestational diabetes mellitus（GDM) and their levels of hepatocyte growth factor and adipocytokines. Methods: A total of 112 pregnant women with GDM were selected in observation group, and were divided into group A (61 women with mild GDM) and group B (51 women with severe GDM of ≥2 abnormal items of OGTT) from January 2019 to January 2020. 112 healthy pregnant women who underwent regular antenatal examination were selected in control group during the same period. Biochemical indicators levels, such as blood glucose and blood lipid, and the levels of serum inflammatory factors, hepatocyte growth factor and adipocytokines of the women in these groups were detected. Results: The levels of fasting blood glucose (FBG), total cholesterol (TC), and triglyceride (TG), and the insulin resistance index (HOMA-IR) value of the women in the observation group were significantly higher than those of the women in the control group, while the insulin sensitivity index (ISI) level of the women in the observation group was significantly lower. The levels of serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), hypersensitive C-reactive protein (HS-CRP), leptin (Lp), retinol binding protein 4 (RBP4) of the women in the observation group were significantly higher than those of the women in the control group, while the levels of hepatocyte growth factor (HGF) and adiponectin (APN) of the women in the observation group were significantly were lower (all P<0.05). The levels of serum inflammatory factors, such as TNF-α, hs -CRP, and IL-6, Lp, and RBP4 of the women in group B were significantly higher than those of the women in group A, while the levels of HGF and APN of the women in group B were significantly lower (all P<0.05). The levels of serum inflammatory factors, such as TNF-α, hs-CRP, and IL-6, were negatively correlated with the HGF level or APN level, but were positively correlated with the Lp level or RBP4 level (all P<0.01). Conclusion: The levels of serum HGF and APN of the pregnant women with GDM are negatively correlated with their inflammatory factors, and the Lp and RBP4 levels are positively correlated with their inflammatory factors. The levels of serum inflammatory factors, hepatocyte growth factors, and adipocytokines of the pregnant women with GDM should be paid close attention to, which is of great significance for the clinical diagnosis and treatment of GDM.
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