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Abstract To analyze the serological screening results of toxoplasma gondii(TOX), rubella virus(RV), cytomegalovirus(CMV), and herpes simplex virus(HSV) of the pregnant women, and to study their relevant to their adverse pregnancy outcomes. Methods: 3065 pregnant women who underwent prenatal examination and TORCH serological detection from January 2019 to January 2020 were selected as the research objects, among them, there were 1725 women <35 years old and 1340 women ≥35 years old. These women were followed up, and 229 pregnant women were lost to follow-up. 2836 pregnant women who had completed the followed up were divided into group A(178 women with adverse pregnancy outcomes) and group B(2658 women with normal pregnancy outcomes). The serum IgM antibody of TOX, RV, CMV, and HSV -Ⅰ and HSV -Ⅱ were detected by colloidal gold method. Results: Among the 3065 pregnant women, 98 cases were positive for TORCH IgM, with the infection rate of 3.2%. The highest positive rate was CMV IgM(2.0%), followed by HSV-ⅠIgM(0.5%), HSV-Ⅱ IgM(0.4%), TOX IgM(0.2%), and RV IgM(0.2%). The positive rate of CMV IgM of the pregnant women in spring and autumn was significantly higher than that of the pregnant women in summer and winter. The positive rates of CMV IgM, HSV-ⅠIgM, and HSV-Ⅱ IgM of the pregnant women <35 years old were significantly higher than those of the pregnant women≥35 years old(P<0.05). The positive rates of TOX IgM, RV IgM, CMV IgM, HSV-Ⅰ IgM, and HSV-ⅡIgM of the women in group A were significantly higher than those of the women in group B(P<0.05). Logistic multifactor regression analysis showed that <35 years old, and the positive rates of TOX IgM, RV IgM, CMV IgM, HSV-Ⅰ IgM, and HSV-Ⅱ IgM were the independent risk factors of adverse pregnancy outcomes of the pregnant women(P<0.05). Conclusion: CMV infection of the pregnant women among TORCH infection is higher. TORCH infection is closely related to the season, age of the women, and the pregnancy outcomes. Therefore, screening TORCH infection of the pregnant women before pregnancy and during the first trimester of pregnancy is of great significance.
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