To investigate the influence of the responsibility management model on the stress situation during cesarean section, the postoperative VAS score, and the emotional state of the patients who experienced uterine artery embolization and curettage for treating bleeding because of cesarean scar pregnancy (CSP). Methods: A retrospective selection of 102 patients with dangerous CSP who had received uterine artery embolization under bilateral uterine artery interventional angiography and curettage from January 2019 to June 2020 were included in this study. According to the hospital responsibility management model implemented, 51 patients were divided into observation group (patients with responsibility management model) and 51 patients (patients without responsibility management model) in control group. Preoperative and intraoperative stress response indexes, postoperative pain and emotional state of the patients in the two groups were analyzed. Results: All the patients in both groups had no severe bleeding and all had successfully surgical treatment. The levels of intraoperative serum cortisol (185.55±4.99 pg/ml) and corticotrophin (80.23±5.62 pg/ml) of the patients in the observation group were significant lower than those (213.71±5.67 pg/ml and 95.33±4.94 pg/ml) of the patients in the control group. The postoperative VAS score (3.07±0.49 points) of the patients in the observation group was significant lower than that (4.76±0.53 points) of the patients in the control group, and the SAS and SDS scores of the patients in the observation group were significant lower than those of the patients in the control group. Treatment satisfaction (94.1%) of the patients in the observation group was significant higher than that (72.6%) of the patients in the control group (P<0.05). Conclusion: The responsibility management model can effectively reduce the stress response of the patients during uterine artery embolization and curettage, and can reduce the postoperative VAS score of the patients, improve their emotional state, and increase their treatment satisfaction.