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| Correlation of serum HMGB1, vitamin D25-(OH) -D, and adiponectin and gestational hypertension |
| The Second Affiliated Hospital of Shandong First Medical University, Tai 'an, Shandong Province, 271000 |
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Abstract To investigate the correlation between the changes of serum HMGB1, vitamin 25-(OH)-D, and adiponectin (APN) levels of the pregnant women and their gestational hypertension occurrence, and to analyze of the mechanism of gestational hypertension. Methods: 60 pregnant women with gestational hypertension were selected in observation group from July 2019 to July 2020, and 60 healthy pregnant women were selected in control group. The levels of serum HMGB1, vitamin 25-(OH)-D, and APN of these women were detected. The correlation between the changes of serum HMGB1, vitamin 25-(OH)-D, and APN levels of the women and their gestational hypertension occurrence was analyzed by Spearman. Results: The levels of serum HMGB1 (4.16±0.79 mg/L) of the women in the observation group was significant higher than that (0.53±0.12 mg/L) of the women in the control group, but the levels of vitamin 25-(OH)-D (20.48± 1.46ug /L) and APN (8.86±1.17mg /L) of the women in the observation group were significant lower than those (36.75±0.59ug /L and 15.93± 3.49mg /L) of the women in the control group (P＜0.05). The serum HMGB1 level was positively correlated with gestational hypertension occurrence (r=0.847, P=0.015), but the serum vitamin 25-(OH)-D level was negatively correlated with gestational hypertension occurrence (r=-0.721, P=0.037), and the serum APN level was negatively correlated with pregnancy hypertension occurrence (r=-0.629, P=0.043). Conclusion: There is correlation between the changes of the serum HMGB1, 25-(OH)-D, and APN levels of the pregnant women and their gestational hypertension occurrence, so the predicting the changes of the serum HMGB1, 25-(OH)-D, and APN levels of the women effectively may improve their pregnancy outcomes.
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