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| The value of thromboelastography combined with platelet aggregation rate for predicting the outcomes of recurrent spontaneous abortion of the women with prethrombotic state |
| Kaizhou District People's Hospital, Chongqing, 405400 |
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Abstract To study the value of thromboelastography combined with platelet aggregation rate for predicting the outcomes of recurrent spontaneous abortion (RSA) of the women with prethrombotic state. Methods: In this prospective study, 80 women with RSA were selected in observation group from January 2018 to January 2020, and 50 healthy women were selected in control group during the same period. The values of the indexes of thromboelastography (R, MA, K, and αAngle), platelet aggregation rate, coagulation index (APTT, PT, and TT), and hemorheology index (LRV, HRV, PV, and MRV) of the women were compared between the two groups. The value of thromboelastography combined with platelet aggregation rate for predicting the outcomes of RSA of the women with prethrombotic state was analyzed. Results: The values of R and MA of the women in the observation group were significant higher than those of the women in the control group (P＜0.05), but there were no significant differences in the values of K and α-Angle of the women between the two groups (P＞0.05). The platelet aggregation rate of the women in the observation group was significant higher than that of the women in the control group, but the values of APTT, PT, and TT of the women in the observation group were significant lower than those of the women in the control group. The LRV value of the women in the observation group was significant higher than that of the women in the control group, but the values of HRV and PV of the women in the observation group were significant lower than those of the women in the control group (all P＜0.05). There was no significant difference in MRV value of the women between the two groups (P＞0.05). The specificity and area under ROC curve of thrombus elastigram combined with platelet aggregation rate for diagnosing RSA were significant higher than those of thrombus elastigram or platelet aggregation rate alone, and which R and MA values of thrombus elastigram, and platelet aggregation rate were 7.88min, 64.79mm, and 57.44%, respectively. Conclusion: The thromboelastography combined with platelet aggregation rate for diagnosing the outcomes of RSA of the women with prethrombotic state has high specificity, so it is recommended to be popularized in clinic.
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