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| Relationship between anti-sperm antibody positive rate, concentration of sperm, forward motility of sperm, and atypical forms of sperm of the man and their pregnancy outcomes after artificial insemination |
| 1. Wenchang People's Hospital, Hainan Province, 571300; 2. The Second Affiliated Hospital of Hainan medical University |
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Abstract To investigate the relationship between anti-sperm antibody (AsAb) positive rate, concentration of sperm, forward motility of sperm, and atypical forms of sperm of the man and their pregnancy outcomes after artificial insemination. Methods: 152 male infertility patients were selected as study subjects from January 2017 to September 2020. The AsAb positive rate of these patients was detected by Mixed Antiglobulin Reaction (MAR), and these patients were divided into group A (57 patients with AsAb positive) and group B (95 patients with AsAb negative) according to the test results of AsAb. The classification of antibody binding sites of the patients in group A was observed. The concentration of sperm and the rates of motility, normal morphology, and forward motility of sperm of the patients were compared between the two groups. Spearman correlation was used to analyze the correlation between AsAb positive rate of the patients and their seminal parameters. Results: The positive adhesion rate of sperm of the patients in group A was 14.0%, which included 5 cases with tail adhesion of sperm, 2 cases with head adhesion of sperm, and 1 case with neck adhesion of sperm. The sperm density, total sperm motility, and forward motility sperm rate of the patients in group A were significant lower than those of the patients in group B, and the normal morphology sperm rate of the patients in group A was significant higher than that of the patients in group B (P<0.05). There were no significant differences in pregnancy rate and abortion rate of the patients after artificial insemination between the two groups (P>0.05).AsAb positive rate was negatively correlated with the sperm density, the total sperm motility rate, the sperm forward motility rate, or normal sperm morphology rate (P<0.05). Conclusion: AsAb positive has significant impact on concentration of sperm, forward motility of sperm, normal morphology of sperm, and pregnancy outcome after artificial insemination.
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