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| The association the levels of vitamin D and anti-Müllerian hormone in serum and in seminal plasma of male infertile patients with their semen parameters and sex hormone levels |
| Huaihe Hospital of Henan University, Kaifeng, Henan Province, 475000 |
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Abstract To explore the association of the levels of vitamin D［25(OH)D］and anti-Müllerian hormone (AMH) in serum and in seminal plasma of male infertile patients with their semen parameters and sex hormone levels. Methods: A total of 144 male infertile patients were selected and divided into group A (37 patients with oligospermia), group B (39 patients with weak sperm), group C (32 patients with less weak sperm), and group D (36 patients with normal semen parameter) according to semen parameters from January 2017 to December 2019. The association of the levels of vitamin D and AMH in serum and in seminal plasma of the patients with their semen parameters was analyzed. Results: The sperm concentration value, serum T level, and serum AMH and 25(OH)D levels of the patients in group A and group B were significant lower than those of the patients in group C and group D, but the semen volume and serum FSH level of the patients in group A and group B were significant higher. The PR value of the patients in group B and group C was significant lower than those of the patients in group A and group D (P＜0.05). There were no significant different in the serum levels of luteinizing hormone, estradiol, prolactin, 25(OH) D, and AMH of the patients among the four groups (P＞0.05). Spearman correlation analysis showed that the levels of 25(OH)D and AMH of the patients were negatively correlated with their semen volume (r=-0.352, -0.309, P＜0.05), but were positively correlated with their sperm concentration and testosterone level (r=0.410, 0.403, 0.287, 0.329, P＜0.05). There was no correlation between serum and seminal plasma 25(OH) D level of the patients and their serum and seminal plasma AMH level (P＞0.05). Conclusion: The levels of 25(OH)D and AMH in seminal plasma of male infertile patients have certain correlation with their semen parameters and sex hormone levels, and the expression levels of which can reflect the testicular spermatogenic function of the patients.
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