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Abstract To explore the application value of sentinel lymph node (SLN) identified by different tracers, such as methylene blue and nano-carbon, in preoperative guidance of endometrial cancer. Methods: From January 2018 to January 2020, 82 patients with endometrial cancer were selected and were divided into group A (SLN of 41 patients identified by methylene blue) and group B (SLN of 41 patients identified by nano-carbon) by computer random number method. The patients in the two groups were injected with methylene blue or nano-carbon in the cervix before surgery. The biopsy was used to observe the coloring of lymph nodes. The first colored lymph nodes were identified, marked and excised as SLN. The average tracing time, tracing duration, and SLN identification situation were compared between the two tracers. Taking postoperative pathological examination results as the gold standard, the accuracy of the two tracers in identifying SNL transfer was evaluated, and the SLN distribution and complications and adverse reactions rates of the patients in the two groups were recorded. Results: The tracing time (16.7± 3.3 s) of the patients in group B was significant shorter than that (37.5± 5.2s) of the patients in group A, but the tracing duration (25.2±5.1s) of the patients in group B was significant longer than that (0.7± 0.2s) of the patients in group A (P＜0.05). The total detection rate, bilateral detection rate, and averag number of SLN detected had no significant difference between the two tracers, and there were no significant difference in the sensitivity, the accuracy, and the negative predictive value of SNL metastasis between the two tracers (all P＞0.05). A total of 292 SLNs were detected in 82 patients with endometrial carcinoma, which mainly distributed in the external iliac lymph node region (38.4%) and obturator lymph node region (35.6%). Conclusion: Methylene blue and nano-carbon as tracers for identifying SLN of the patients with endometrial cancer have high value, which have guiding significance for determining the range of lymph node dissection during surgery, but nano-carbon tracer has shorter tracing time, longer duration, and higher stability.
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