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| Comparative anesthetic effect of alfentanil and sufentanil for painless abortion of women and its influence on their postoperative inflammatory response |
| Maternal and Child Health Care Hospital of Qinghai Province, Xining, Qinghai Province, 810000 |
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Abstract To compare the anesthetic effect of alfentanil and sufentanil for painless abortion of the women, and to study its influence on the postoperative inflammatory response painless abortion of the women. Methods: 137 women who wanted painless abortion were selected and were randomly divided into group A (66 women given 10μg/kg of alfentanil for analgesia) and group B (71 women given 0.15μg/kg of fentanyl for analgesia), and the women in both groups were given propofol for maintain sedation. The wakening time and the total operation time, the propofol dosage, and the incidence of cardiopulmonary complications of the women in both groups were recorded. The C-reactive protein level and the white blood cell (WBC) count of the women in both groups were compared before and after abortion. Results: The dosage of propofol used (151.5±29.1mg) of the women in group A was significant higher than that (123.2±28.3 mg) of the women in group B, but the wakening time (5.3±3.5 min) and the recovery time (10.8±2.6 min) of the women in group A were significant lower than those (6.6±3.9 min and 13.1±3.1 min) of the women in group B (P<0.05). There were no significant differences in the decreasing values of mean arterial pressure, mean heart, and mean arterial pressure, and the rates of hypoxemia, non-invasive positive pressure ventilation, and the cardiopulmonary related complications of the women between the two groups (P>0.05). The proportion of vasoactive drug application of the women in group A was significant lower than that of the women in group B, and the level of hs-CRP at postoperative 3h of the women in group A was significant lower than that of the women in group B (all P<0.05). There was no significant difference in WBC count of the women between the two groups (P>0.05). Conclusion: Compared with those of fentanyl, alfentanil can effectively relieve pain of the women during abortion, with shorter recovery time, more stable during operation, and lower postoperative inflammatory level.
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