To investigate the influence of low molecular weight heparin and progesterone combined with folic acid for treating patients with recurrent miscarriage on their lymphocyte subsets, sex hormones levels, and repregnancy outcomes. Methods: 94 patients with recurrent miscarriage were included and were randomly divided into observation group and control group (47 cases each group) according to the digital table method from January 2018 to December 2019. The patients in the control group were treated with progesterone combined with folic acid, and the patients in the observation group were treated with low molecular weight heparin and progesterone combined with folic acid. The lymphocyte subgroup indexes (CD3+, CD3+CD4+, CD3+/CD8+, CD3+/CD8+, CD4+/CD8+), sex hormones levels, re-pregnancy outcomes, and adverse reactions rate during medication of the patients were analyzed and compared between the two groups. Results: After treatment, the levels of CD3+/CD8+, serum human chorionic gonadotropin, progesterone, and estradiol of the patients in both groups had increased significantly, while the levels of CD4+/CD8+ of the patients in both groups had decreased significantly, and the changes of which of the patients in the observation group were significant better than those of the patients in the control group (P<0.05). The rate of adverse pregnancy outcomes (12.8%) of the patients in the observation group was significant lower than that (29.8%) of the patients in the control group, and there was no significant difference in adverse reactions rate during medication (12.8% vs. 14.9%) of the patients between the two groups (P>0.05). Conclusion: Low molecular weight heparin and progesterone combined with folic acid for treating patients with recurrent miscarriage can increase the curative effect, which can improve lymphocyte subsets and sex hormones levels, can  prevent miscarriages with high safety.