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| Embryo extraction by laparoscopic window combined with local injection of methotrexate for treating ectopic pregnancy |
| The fourth hospital of Xi'an, Xi'an, Shaanxi Province, 710000 |
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Abstract To explore the therapeutic effect of local injection of methotrexate combined with embryo extraction by laparoscopic window or treating ectopic pregnancy. Methods: 200 patients with ectopic pregnancy who underwent embryo extraction by laparoscopic window were selected as observation objects and were divided into two groups according to different treatment plans, (100 cases in each group) from February 2018 to February 2020. After embryo extraction by laparoscopic window, the patients in the control group were given routine postoperative oral mifepristone treatment and the patients in the observation were given methotrexate injected locally. The tubal repatency rate, the time of hospital stay, the repregnant situation, and the change of human chorionic gonadotropin (β-HCG) levels of the patients were compared between the two groups. Results: The level of serum β-HCG (78.15±32.28 U/L) of the patients in the observation group 1 week after treatment was significant lower than that of the patients in the control group, and the time of β-HCG level return to normal (8.9±2.4d) and hospital stay (5.2±1.4d) of the patients in the observation group were significant lower than those of the patients in the control group. The proportions of completely unblocked oviduct (73.0%), partially unblocked oviduct (20.0%), and unblocked oviduct (7.0%) of the patients in the observation group 3 months after operation were significant better than those (48.0%, 28.0%, and 24.0%) of the patients in the control group. The normal delivery after intrauterine pregnancy (55 cases, 55.0%) of the patients in the observation group was significant better than that (38 cases, 38.0%) of the patients in the control group (all P＜0.05). Conclusion: Embryo extraction by laparoscopic window and local injection of methotrexate for treating ectopic pregnancy of the women can shorten the hospitalization time of patients and the time of serum β-HCG level reducing to normal, which is helpful to increase the effect of fallopian tube fluid, and can promote the normal pregnancy and delivery of the women.
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