|
Abstract To investigate the effect of medroxyprogesterone combined with compound sophora flavescens injection on serum tumor markers levels and immune function of patients with endometrial carcinoma. Methods: From March 2017 to March 2019, 86 patients with endometrial cancer were selected and divided into observation group and control group (43 cases in each group) according to the method of random digital table. All patients were given the same chemotherapy regimen. In addition, the patients in the control group were treated with medroxyprogesterone acetate, and the patients in the observation group were treated with compound sophora flavescens injection on the basis of the treatment in the control group. The levels of the serum tumor markers and the relevant indexes of the immune function, and the value of living state related indexes, the scores of KPS, the treatment effect, and the occurrence rate of the adverse reactions of patients were compared between the two groups. Results: After treatment, the levels of serum human epididymal protein 4 (HE4), carcinoembryonic antigen (CEA), carbohydrate antigen 125(CA125) of patients in both groups had decreased significantly, but KPS score, body mass value, and daily food intake of the patients in both groups had increased significantly, and the changed degree of these indexes of patients in the observation group were significant more than those of patients in the control group. The levels of CD3, CD4, and CD4/CD8 of patients in the observation group had increased significantly after treatment, but the CD8 level had decreased significantly. The objective remission rate of patients in the observation group (76.1%) and clinical benefit rate (100.0%) of patients in the observation group were significant higher than those (51.2% and 88.4%) of patients in the control group, and the adverse reaction rate of patients in the observation group (30.2%) was significant lower than that (65.1%) of patients in the control group (all P＜0.05). Conclusion: Medroxyprogesterone combined with compound sophora flavescens injection for treating patients with endometrial carcinoma has a good clinical effect, which can obviously inhibit the growth of tumor, enhance the immune function, and improve the living conditions of patients with less side effects, so it is worthy of clinical application.
|
|
|
|
|
|
