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| The influence of estrogen application days in hormone replacement cycle of women with frozen-thawed embryo transfer on their pregnancy outcomes |
| Research Institute of Family Planning of Hebei Province, Key Laboratory for Family Planning and Birth Health of the National Health and Family Planning Committee, Key Medical Laboratory of Hebei Province, Shijiazhuang，Hebei Province, 050000 |
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Abstract To investigate the influence of estrogen application days in hormone replacement cycle of women with frozen thawed embryo transfer on their pregnancy outcomes. Methods: A retrospective analysis was conducted on 1034 cycles of frozen thawed embryo transfer of women from January 2016 to February 2019. According to the different drugs used, the women were divided into group A (334 cycles with femoston used) and group B group (700 cycles with progynova used). And according to the application days of femoston, the women in group A were further divided into group A1 (women with femoston used >7 d- ≤10d), group A2 (women with femoston used >10 d- ≤12d), group A3 (women with femoston used >12 d-≤15d), and group A4 (women with femoston used >15 d ≤24d). And according to the application days of progynova, the women in group B were further divided into group B1 (women with progynova used >7 d- ≤10d), group B2 (women with progynova used >10 d- ≤12d), group B3 (women with progynova used >12 d- ≤15d), and group B4 (women with progynova used >15 d- ≤27d). The general condition, serum estradiol (E2) level on the day of endometrial transformation, the endometrial thickness, the embryo transfer situation, and clinical pregnancy outcomes of women were compared among these groups. Results: The E2 level, the endometrial thickness, and the application days of estradiol of women in group A were significant higher than those of women in group B (P＜0.01). There were no significant differences in general condition, embryo transfer situation, and clinical pregnancy outcomes of women between group A and group B (P>0.05). In subgroup A, the E2 level on the day of endometrial transformation of women in group A4 was significant higher than that of women in group A1, group A2, and group A3, and the endometrial thickness of women in group A4 was significant thinner than that of women in other 3 groups (all P＜0.05). The endometrial thickness on the day of endometrial transformation of women in group A3 was significant thinner than that of women in group A1 (P＜0.01). However, there were no significant differences in the general conditions, embryo transfer situation, and clinical pregnancy outcomes of women among group A1, A2, A3 and A4 (P>0.05). In group B，the endometrial thickness on the day of endometrial transformation of women in group B1, B2, B3, and B4 had become thinner in turn (P＜0.05). The E2 level of women in group B2 was significant lower than that of women in group B4 (P＜0.05), but there were no significant differences in the general conditions, embryo transfer situation, and clinical pregnancy outcomes of women among group B1, B2, B3 and B4 (P>0.05). Conclusion: The clinical pregnancy outcomes of women with femoston or progynova for preparing their endometrium are similar during hormone replacement cycles. The clinical pregnancy outcomes of women with different days of estradiol used are also similar, which suggests that the pregnancy outcomes of women after frozen-thawed embryo transfer may not be related to the days of estradiol used.
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