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| Effect of goserelin acetate sustained-release implant combined with laparoscopic surgery for treating women with endometriosis |
| Longgang District People's Hospital, Shenzhen, Guangdong Province, 518172 |
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Abstract To investigate the effect of goserelin acetate sustained-release implant combined with laparoscopic surgery for treating women with endometriosis. Methods: 80 women with endometriosis were selected and were randomly divided into 2 groups (40 cases in each group). These women had received laparoscopic surgery according to the r-AFS staging. The women in the study group were given goserelin acetate sustained-release implant 3.6 mg, 1 times every 4 weeks for 6 months, and the women in the control group were given received gestation three ketone 2.5mg, 1 times every 2 weeks for 6 months. The clinical effect of women was compared between the two groups. The levels of serum vascular endothelial growth factor (VEGF), matrix metalloproteinase-9/tissue inhibitor of metalloproteinase -1 (MMP-9/TIMP-1) of women in the two groups were detected before operation and 6 months after operation. The scores of visual analogue scale (VAS) and health-related quality of life assessed by SF-36 questionnaire of women in both groups were recorded. And the rates of recurrence and adverse reaction of women in both groups in 3 years after operation were oversexed. Results: The effective rate of women in the control group (75.0%) was significant lower than that (92.5%) of women in the study group (P＜0.05). 6 months after operation, there were no significant different in the serum VEGF level (158.41±56.28 ng/L vs. 119.63±47.13ng/L), MMP-9/TIMP-1 (1.35±0.25 vs. 1.14±0.23), physiological health score (64.20±12.81 points vs. 78.53±13.23 points), mental health score (69.14±13.26 points vs. 80.35±14.59 points), and VAS scores (1.21±0.46 points vs. 0.84±0.39 points) of women between the two groups (P＜0.05). No case with adverse reactions occurred in the study group. The recurrence rate of women in the control group in 3 years after operation (27.5%) was significant higher than that (10.0%) of women in the study group (P＜0.05). Conclusion: Goserelin acetate sustained-release implant combined with laparoscopic surgery for treating women with endometriosis has definite effectiveness, which can reduce the vascular invasion index levels and the recurrence rate, and improve the quality of life with high safety.
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