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Abstract To analyze the clinical features of previous gestational diabetes mellitus (GDM) of women, and to study its influence on the recurrence of GDM. Methods: The clinical data of 306 pregnant women with previous GDM from January 2017 to October 2019 were collected retrospectively. According to the diagnostic criteria of GDM, these women were divided into group A (women with recurrent GDM) and group B (women without recurrent GDM). And according to the results of OGTT, the women in group A were further divided in Group A1 (women with abnormal FPG), group A2 (women with normal FPG and abnormal 1hPG and/or 2hPG) and group A3 (women with abnormal FPG and 1hPG and/or 2hPG). The clinical features of previous GDM of the women were compared among these groups, and the relationship between previous GDM and the recurrence of GDM was analyzed. Results: There were significant different in age, the proportion of delivery interval ≥5 years, the values of FPG, 1hPG and 2hPG, and the proportions of OGTT abnormal types and insulin used during previous pregnancy of women between group A and group B (P＜0.05), while there were no significant different in BMI, weight gain during pregnancy, and incidence of preterm birth of previous pregnancy of women between group A and group B (P＞0.05). Age ≥35 years old, and 2hPG>9.10mmol/L, the abnormal 1hPG and/or 2hPG, and abnormal FPG and 1hPG and/or 2hPG of previous pregnancy of women were the risk factors of their recurrence of GDM (P＜0.05), while delivery interval ≥5 years, and FPG>5.35mmol/L and 1hPG>10.59mmol/L, and the proportion of insulin used during previous pregnancy had no correlation with recurrence of GDM (P＞0.05). There were significant different in age, and the values of 1hPG and 2hPG during previous pregnancy of women between group A3 and group A1 (P＜0.05), while those had no significant different between group A3 and group A2, and between group A1 and group A2 (P＞0.05). There were significant different in the proportions of OGTT abnormal types and insulin used during previous pregnancy of women among group A1, A2, and A3 (P＜0. 001), while there were no significant different in the proportion of delivery interval ≥5 years, the incidences of preterm birth and insulin used during previous pregnancy of women among group A1, A2, and A3 (P＞0.05). Age ≥35 years old, and abnormal FPG and 1hPG and/or 2hPG values of previous pregnancy were the risk factors of the women with recurrence of GDM and glucose abnormality (P＜0.05), while 1hPG>10.59mmol/L and 2hPG>9.10mmol/L, and the abnormal 1hPG and/or 2hPG values during previous pregnancy had no correlation with the recurrent GDM of women with OGTT abnormality (P＞0.05). Conclusion: The age of pregnant women, the 2hPG value, and the abnormal OGTT type of women during previous pregnancy may affect the incidence and severity of the recurrent GDM.
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