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| Value of transvaginal color Doppler ultrasound combined with serum HE4 and MiR-21 levels of women for diagnosing endometrial carcinoma early |
| The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei Province, 075000 |
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Abstract To investigate the value of transvaginal color Doppler ultrasound (TVCDS) combined with HE4 and microRNA-21 levels for diagnosing endometrial carcinoma early. Methods: From March 2017 to January 2019, 91 patients with early endometrial cancer confirmed by pathological examination were selected in group A, and 86 patients with benign endometrial lesion confirmed by pathological examination after elective surgery were selected in group B. All patients were examined by TVCDS and their serum HE4 and microRNA-21 levels were detected before operation. The images by TVCDS of the patients in the two groups were observed. The value of TVCDS, and HE4 and microRNA-21 levels for diagnosing endometrial cancers early were evaluated based on the pathological biopsy results. Results: The results of TVCDS showed that the main features of early endometrial cancer were the enlargement of uterine morphology, interruption of hypoechoic halo between the serosa and the endometrium of uterus, lesion invasion of endometrum and myometrium of uterus, abundant signals and proliferation of neovascularization. There was significant difference in the blood flow signals of lesion of the patients between the two groups (P<0.05). The blood flow signals of lesion of the patients in group A were mostly dendritic or reticular, while those of the patients in group B were mostly punctate or short rod. The endometrial thickness, serum HE4 and microRNA-21 levels of the patients in group A were significant higher than those of the patients in group B, while the pulsation index and resistance index of the patients in group A were significant lower (P<0.05). The specificity and the sensitivity of TVCDS for diagnosing
endometrial carcinoma were 80.4% and 83.5%, respectively. The critical value, the specificity, and sensitivity of HE4 level for diagnosing endometrial carcinoma were 71.35 pmol/L, 78.3%, and 85.9%, respectively. The critical value, the specificity, and sensitivity of miR-21 level for diagnosing endometrial carcinoma were 1.32, 85.7%, and 88.4%, respectively. The specificity, the sensitivity, and Jorden index of TVCDS combined with serum HE4 and MiR-21 levels for diagnosing endometrial carcinoma were 95.1%, 94.5%, and 0.899, respectively, which were significant higher than those of TVCDS, serum HE4 level, or the MiR-21 level alone (F=15.382, P<0.05). Conclusion: The HE4 and miR-21 levels of patients with early endometrial carcinoma are both increase, and TVCDS combined with serum HE4 and MiR-21 levels for diagnosing endometrial carcinoma can increase the diagnostic efficiency of early endometrial carcinoma.
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