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Abstract To analyze the characteristic of different types of high hyperandrogenism and glycolipid metabolism of women with polycystic ovary syndrome (PCOS), and to study their islet function situation. Methods: The women with PCOS were selected in this study from January 2017 to October 2019. And according to the levels of serum testosterone (T) and androstenidone (AND), these women were divided into group A (women with normal levels of T and AND), group B (women with high level of T), group C (women with high level of AND), and group D (women with high levels of T and AND). The differences of sex hormone level, glycolipid metabolism, and islet function of women in these groups were analyzed. Results: There were no significant differences in mF-G score and incidence of hirsutism of women among group B, group C, and group D (P＜0.05), but those of women in group B, group C, and group D were significant higher than those of women in group A (P＜0.05). There were no significant differences in age, ovulation disorder rate, BMI, and WHR of women among these four groups (P＞0.05). LH level and LH/FSHB value of women in group B, group C, and group D were significant higher than those of women in group A, and those of women in group C and D were significant higher than those of women in group B (all P＜0.05), but those of women in group C had no significant different from those of women in group D (P＞0.05). There were no significant differences in levels of E2, PRL, and FSH of women among these four groups (P＞0.05). The levels of FINS, TC, and LDL of women in group B, group C, and group D were significant higher than those of women in group A, and those of women in group C and D were significant higher than those of women in group B (all P＜0.05), but those of women in group C had no significant different from those of women in group D (P＞0.05). There were no significant differences in levels of FPG, TG, and HDL of women among these four groups (P＞0.05). The HOMA-IR value of women in group B, group C, or group D was significant higher than that of women in group A, and that of women in group C or D was significant higher than that of women in group B, but the HOMA-βvalue of women in group C or D was significant lower than that of women in group B (all P＜0.05). The values of HOMA-IR and HOMA-β of women in group B had no significant different from those of women in group D (P＞0.05). There were no significant differences in values of ISI, GLU-AUC, and INS-AUC of women among these four groups (P＞0.05). Conclusion: The women with PCOS and high AND has more serious abnormal glucose lipid metabolism and insulin resistance.
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