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| Effect of serum levels of vascular endothelial growth factor and sFlt-1 combined with Doppler ultrasonography for diagnosing placental implantation of pregnant women |
| Southern branch of affiliated Hospital of Chengde Medical College, Chengde, Hebei Province, 067000 |
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Abstract To explore the value of serum levels of vascular endothelial growth factor (VEGF) and sFlt-1 combined with Doppler ultrasonography for diagnosing placental implantation of pregnant women. Methods: Pregnant women were selected in this study randomly from 2016 to 2018. The venous blood of these women during 28 gestational weeks were collected, and their levels of serum VEGF and sFlt-1 were detected by ELISA. These women were divided into group A (women with placental implantation) and group B (women without placental implantation) based on the results of placenta pathology after delivery as the gold standard. The serum levels of VEGF and sFlt-1 of women in the two groups were analyzed. And the effect of different methods of diagnosing placental implantation was also analyzed. Results: Serum VEGF level of women in group B (249.37±18.23 pg/ml) was significant lower than that (335.24±16.95 pg/ml) of women in group A, but the SFLT-1 level of women in group B (2939.93±28.99 pg/ml) was significant higher than that(2483.56±28.67 pg/ml) of women in group A. Serum VEGF and SFLT-1 levels of women during the third trimester of pregnancy were significant higher than those of women during the first and the second trimester of pregnancy, and those of women during the second trimester of pregnancy were significant higher than those of women during the first trimester of pregnancy. In group A, the serum VEGF and SFLT-1 levels of women with deep placental implantation were significant higher than those of women with shallow placental implantation (all P＜0.05). The coincidence rate of the levels of serum VEGF and sFlt-1 combined with color ultrasound for diagnosing placental implantation was 88.6%, which had the highest diagnostic sensitivity (87.9%) and the lowest missed diagnosis rate (11.4%). Conclusion: The levels of serum VEGF and sFlt-1 combined with color ultrasound for diagnosing placental implantation of pregnant women has good clinical guiding significance.
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