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| Clinical efficacy of levothyroxine sodium for treating pregnant women with TPoAb negative of subclinical hypothyroidism |
| Zhangjiagang Hospital affiliated to Soochow University, Jiangsu Province, 215600 |
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Abstract To investigate the clinical efficacy of levothyroxine sodium (L-T4) for treating pregnant women with thyroid peroxidase antibody（TPOAb） negative of subclinical hypothyroidism. Methods: 140 pregnant women with TPO-Ab negative of subclinical hypothyroidism were randomly divided into two groups (70 cases in each groups). The women in experimental group were treated with L-T4 combined with routine treatment, and the women in experimental group were treated with routine treatment. The rates of pregnancy outcomes and pregnant complications of women in both groups were observed. Results: The abortion rate (8.6%) and preterm birth rate (4.3%) of women in experimental group were significant lower than those (14.6% and 10.0%) of women in the control group. The levels of serum total cholesterol, triacylglycerol and low-density lipoprotein of women in experimental group were significant higher than those of women in the control group, but the high-density lipoprotein level was significant lower. The improvement of thyroid function indexes of women in experimental group was significant better than that of women in the control group (all P＜0.05). The incidence of gestational hypertension (5.1%), anemia (21.6%), gestational diabetes (2.9%), or intrahepatic cholestasis (2.9%) was significant lower than that of women in the control group (P＜0.05). Conclusion: L-T4 can improve thyroid function, perioperative outcomes, and reduce the incidence of complications of women with TPOAb negative of subclinical hypothyroidism significantly.
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