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| Effect of single-dose amoxicillin-clavulanic acid for preventing postpartum infection of women after vaginal delivery and the influence factor of infection |
| Chongzuo Maternal and Child Health Care Hospital, Guangxi Zhuang Autonomous Region,532200 |
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Abstract To investigate the effect of single-dose amoxicillin-clavulanic acid for preventing postpartum infection of women after vaginal delivery, and to study the influence factor of infection. Methods: 1003 women who underwent vaginal delivery were randomly divided into the experimental group (507 cases) and the control group (496 cases) from February 2016 to April 2019. The women in the experimental group were given 20ml amoxicillin-clavulanate potassium dry suspension (7:1) within 3-6 hours after delivery, and the women in the control group were not given any antibiotics after delivery. The infection situation within postpartum 42 days of women in the two groups were followed up. The risk factors of postpartum infection was analyzed. Results: There were no significant different in the rates of conversion cesarean section, perineal side cut, vaginal midwifery, the second stage of labor prolonged, oxytocin used, postpartum hemorrhage, and indwelling catheterization >3 days of women between the two groups (P>0.05). The incidence of postpartum infection was 14.74% (143/970) within 42 days of all women after delivery, and the incidence of postpartum infection of women in the experimental group was 10.86% (53/488), which was significant lower than that (18.67%, 90/482) of women in the control group (χ2=11.773, P=0.000). The rates of vaginal midwifery, perineal side cut, premature rupture of fetal membranes, the second stage of labor prolonged, gestational diabetes mellitus, postpartum hemorrhage, and indwelling catheterization >3 days of women with postpartum infection were significant higher than those of women without postpartum infection. Multivariate logistic regression analysis showed that postpartum infection in women with vaginal midwifery, perineal side cutting, postpartum hemorrhage, or indwelling catheterization >3 days was independent risk factors of postpartum infection (P<0.05). Postpartum application of amoxicillin clavulanate potassium was a protective factor for preventing postpartum infection (P<0.05). Conclusion: Prophylactic application of clavulanate potassium in the early postpartum period can reduce the incidence of postpartum infection. Strict aseptic operation in the perineal side cutting and vaginal midwifery can also reduce the incidence of postpartum infection.
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