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| The influence of Omi/HtrA2 gene and Livin gene of pregnnant women with preeclampsia or eclampsia on their placenta cell apoptosis |
| The First People’s Hospital of Lanzhou, Lanzhou, Gansu Province, 730050 |
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Abstract To detect the expressions of Omi/HtrA2 gene and anti-apoptosis protein Livinin gene in placentas of normal women or women with preeclampsia or eclampsia during the third trimester of pregnancy，and to explore the role of Omi/HtrA2 and Livin in placenta cell apoptosis of women with preeclampsia or eclampsia．Methods: Immunohistochemical SP method was used to detect Omi/HtrA2 and Livin expressions in placental tissues after delivery of 60 women in the observation group and 20 normal pregnant women in control group. Results: Omi/HtrA2 was mainly expressed in trophoblast cells and stromal cells cytoplasm of placental tissues. The expression level of Omi/HtrA2 of women in the observation group was 150.46±26.59, which was significant higher than that (132.11±18.43) of women in the control group, and the expression level of Omi/HtrA2 of women with severe preeclampsia was 161.17±19.45, which was significant higher than that (136.79±26.57) of women with preeclampsia (P＜0.05). Livin was main expressed in the nuclei of syncytiotrophoblast cells and stromal cells in the placental tissues. OD value of women in the observation group (116.07±22.40) was significant lower than that (136.73±20.81) of women in the control group (P＜0.01), but there was no significant different in the Livin expression between women with preeclampsia and women with severe preeclampsia (P＞0.05). Conclusion: Omi/HtrA2 and Livin are both involved in placental cells apoptosis and may play an important role in the occurrence and development of preeclampsia.
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