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| Research progress of the relationship between the PI3K/Akt/mTOR signaling development and maturation of sperm |
| 1. Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing,100091; 2. Graduate School, China Academy of Chinese Medical Sciences; 3. The First Hospital Affiliated to Tianjin University of Traditional Chinese Medicine; 4. The Seventh Hospital of Handan City of Hebei Province |
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Abstract Sperm quality is a key factor in male fertility ability, and the occurrence and development of sperm are closely related to abnormal signaling pathways. The classical PI3K/Akt/mTOR signaling pathway plays an important biological role, which plays an important regulatory role in cell proliferation, differentiation, translation, energy metabolism, and apoptosis. Recent studies have shown that the activation of this pathway is closely related to spermatogenesis and maturation, and also is closely related to the prognosis of male infertility. This review summarizes the role of PI3K/Akt/mTOR signaling pathway in spermatogenesis, maturation, and other processes of sperm to provide new perspectives and ideas for the study of the molecular mechanism of male infertility.
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