Abstract To detect the expression levels of plasma angiotensinogen (AGT) and interleukin-22 (IL-22) of the patients with pregnancy induced hypertension, and to explore the relationships between AGT and IL-22 levels and the renal damage of these patients. Methods: From March 2018 to May 2019, 120 pregnant women with pregnancy induced hypertension were selected in the study group, which included group A (41 women with pregnancy induced hypertension), group B (39 women with mild preeclampsia), group C (40 women with severe preeclampsia), group D (46 women with KI), and group E (74 women without KI). And another 40 normal pregnant women were selected in the control group. The levels of plasma AGT and IL-22 and serum creatinine level of all included women were detected by ELISA. Pearson's method was used to analyze the correlations between the levels of plasma AGT and IL-22 and serum creatinine level of women with renal damage caused by pregnancy induced hypertension. And ROC curve was used to analyze the values of AGT and IL-22 levels, and serum creatinine level for predicting renal damage caused by pregnancy induced hypertension. Results: The levels of plasma AGT and IL-22 of women in the study group were significant higher than those of women in the control group, and which of women in group A, group B, and group C had increased in turn (P＜0.05). The levels of plasma AGT and IL-22, and serum creatinine level of women in group D were significant higher than those of women in group E (P＜0.05). There was a positive correlation between the levels of AGT and IL-22 of women and their serum creatinine level in group D (r=0.591, 0.586, P＜0.05). The sensitivity, the specificity, and area under the curve of the combination of the levels of AGT, IL-22 and creatinine for predicting renal damage of women with pregnancy induced hypertension were 84.8%, 94.6% and 0.936, respectively. Conclusion: The expressions of AGT and IL-22 of women with pregnancy induced hypertension decrease, which are related to the severity of the disease and the complication of KI. The combination of the levels of AGT, IL-22, and creatinine for predicting renal damage has high value, which is expected to be a molecular marker for evaluating renal damage of women with pregnancy induced hypertension.
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