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| Changes and clinical significance of E2, FSH and P levels of women with uterine fibroids |
| 1.Zigong Maternal and Child Health Care Hospital, Sichuan Province, 643200; 2. Guang'an People's Hospital of Sichuan Province |
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Abstract To observe changes of the levels of serum estradiol (E2), follicle stimulating hormone (FSH) and progesterone (P) of women with uterine fibroids (UF), and to study their clinical significance so as to provide evidence for diagnosis and treatment of UF. Methods: 160 women with UF were selected in study group from September 2017 to August 2019. 35 healthy volunteers were selected in control group during the same period. The levels of serum E2, FSH and P of women in the two groups during the middle follicles stage were detected by IMMULITE 1000 automatic biochemical analyzer. The changes of serum E2, FSH and P levels of UF women with different clinical features were analyzed. Spearman correlation parameters were applied to analyze the relationship between serum E2, FSH, P levels and the location and size of fibroids. Results: The serum E2, FSH and P levels of women in the study group were significant higher than those of women in the control group (P＜0.05). ROC curve analysis indicated that the area under the curve of combined detection with serum E2, FSH and P levels for diagnosing UF was 0.982, which had no significant differences among the women with different age and BMI (P＞0.05). However, the serum E2, FSH and P levels of women with uterine fibroids diameter ≥6cm or with cervix fibroids were significant higher (P＜0.05). The serum E2, FSH and P levels of women with UF were significantly positively correlated with their location and diameter of fibroids (P＜0.05). Conclusion: The levels of serum E2, FSH and P of women with UF have increased. The higher levels of serum E2, FSH and P indicate the larger of the uterine fibroids diameter and the higher incidence of cervical uterine fibroids. Active monitoring of changes of serum E2, FSH and P levels of women with UF during middle follicles stage may provide evidence for early diagnosis and treatment of diseases.
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