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Abstract To investigate the value of human epididymal protein 4 (HE4) level for predicting endometrial hyperplasia of women with polycystic ovary syndrome (PCOS). Methods: From March 2016 to December 2018, 198 women with PCOS who had undergone curettage due to infertility or irregular uterine bleeding were selected in study group. And 203 infertility women with who had undergone curettage caused by fallopian tube or male factors were included in control group. The level of serum HE 4 was measured by electrochemiluminescence immunoassay. Multivariate logistic regression was used to analyze the potential factors affected endometrial hyperplasia. The receiver operating characteristic (ROC) was used to evaluate the value of HE4 for predicting endometrial hyperplasia of women with PCOS. Results: Multivariate logistic regression model suggested that BMI ［OR (95% CI): 1.46 (1.25-1.72)］, the value of FBG ［OR (95% CI): 1.31 (1.17-1.48)］, the LDL level ［OR (95% CI) : 1.12 (1.06-1.19)］, the E2 level ［OR (95% CI): 1.24 (1.13-1.36)］, and the HE4 level ［OR (95% CI): 1.29 (1.13-1.46)］ were the independent risk factors of endometrial hyperplasia of women with PCOS. ROC curve showed that the best cut-off value of HE4 level for predicting endometrial hyperplasia in PCOS patients was 102.93 pmol/L, which’s sensitivity, specificity, and the area under curve (AUC) were 77.31%, 97.34%, and 0.830, respectively. Conclusion: HE4 is significantly correlated with endometrial hyperplasia of women with PCOS, which can be used as a biomarker to predict endometrial hyperplasia of women with PCOS.
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