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| Analysis of the changes of T lymphocyte subsets and inflammatory factors levels of patients with cervical HPV infection |
1.The First Affiliated Hospital of Shenzhen University, The Second People's Hospital of Shenzhen, Guangdong Province, 518035；2. Fujian Cancer Hospital |
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Abstract To explore the relationship between the situation of cervical human papilloma virus (HPV) infection of patients with cervical lesions and the changes of their T lymphocyte subsets and inflammatory factors levels. Methods: From October 2017 to June 2019, 200 patients with cervical HPV infection were selected in study group, which included 71 patients with cervical intraepithelial neoplasias (CIN) I, 79 patients with CIN II, and 50 patients with CIN III, included 124 patients with single HPV infection and 76 patients with multiple HPV infection, and also included 72 patients with phase I of cervical cancer, 76 patients with phase II of cervical cancer, 52 patients with phase III of cervical cancer. In addition, 60 healthy women were selected in the control group. The levels of interleukin 4 (IL 4), interferon γ (IFN γ) and interleukin 2 (IL 2) of all included women were detected by enzyme linked immunosorbent assay, and their levels of CD3+, CD4+, and CD8+ were detected by flow cytometry. Results: The levels of IL 4 and CD8+ of patients in the study group were significant higher than those of women in the control group, but the levels of IFN γ, IL 2, CD3+, and CD4+ of patients in the study group were significant lower (P<0.05). The levels of IL 4 and CD8+ of patients with CIN I, CIN II, and CIN III had increased in turn, but their levels of IFN γ, IL 2, CD3+, and CD4+ had decreased in turn (P<0.05). Compared with those of patients with single HPV infection, the levels of IL 4 and CD8+ of patients with multiple HPV infection were significant higher, but the levels of IFN γ, IL 2, CD3+ and CD4+ of patients with multiple HPV infection were significant lower (P<0.05). The levels of IL 4 and CD8+ of patients with stage I, II, and III of cervical cancer had increased in turn, but the levels of IFN γ, IL 2, CD3+ and CD4+ of patients with stage I, II, and III of cervical cancer had decreased in turn (P<0.05). Conclusion: The IL 4 and CD8+ expressions of patients with HPV infection are high, while their IFN γ, IL 2, CD3+, and CD4+ expressions are low, which all change with the increasing of cervical lesion degree and clinical stage, which means that T lymphocyte subsets and inflammatory factors levels of patients play important roles in the cervical HPV infection and development of cervical lesions.
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