Abstract To investigate the reference interval establish of thyroid function of normal pregnant women during different pregnancy period in Shenzhen. Methods: 611 normal pregnant women during different gestational periods were selected in study group, and 225 normal nonpregnant women of childbearing age were selected in control group during the same period. Serum thyroid function indicators, such as the levels of T3, T4, TSH, FT3, and FT4 of women in both groups were tested, and the reference intervals of thyroid function indicators of pregnant women during different pregnant period were established. Results: The levels of T3, T4, and FT4 of women in the study group were significant higher than those of women in the control group (P＜0.05), and there were no significant different in the FT3 and TSH levels of women between the two groups (P＞0.05). There were no significant different in T3 and FT4 levels between pregnant women during the first trimester of pregnancy and the non-pregnant women (P＞0.05), but the level of FT3 of pregnant women during the second trimester of pregnancy had significant different from that of non-pregnant women (P＜0.05). According to the thyroid hormone reference intervals provided by the reagent manufacturer, T3 level of 27.8% women had been misjudged, FT4 level of 5.9% women had been misjudged, but no misjudgments were observed in the levels of T4, FT3 and TSH. The misdiagnosis rates of T3 and FT4 of women during the first trimester of pregnancy were 9.0% and 5.3%, respectively. The misdiagnosis rate of T3 and FT4 of women during the second trimester of pregnancy were 38.3% and 3.6%, respectively. And the misdiagnosis rate of T3 and FT4 of women during the third trimester of pregnancy were 34.7% and 8.4%, respectively. Conclusion: The thyroid function indicators of pregnant women during different pregnant period changes significantly, and the reference ranges of thyroid function indicators during the first, the second, and the third trimester of pregnancy has significant difference. Establishing the local reference ranges of thyroid function indicators of pregnant women will help to reduce over diagnosis and treatment.
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