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| HBV-DNA load in serum, saliva and milk of puerpera with HBV infection |
| Central Hospital of Shandong Energy and Health of Xinwen Mining Group, Shandong Province, 271219 |
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Abstract To detect the HBV-DNA load in serum, saliva and milk of puerpera with HBV infection, and to analyze its guiding significance in clinical practice. Methods: The puerpera with chronic hepatitis B virus (HBV) infection were selected in this study from January 2016 to December 2018, and they were divided into group A (puerpera with HBsAg, HBeAg, and Anti-HBc positive), group B (puerpera with HBsAg, Anti-HBe, and Anti-HBc positive), and group C (puerpera with HBsAg, and HBeAg or Anti-HBc positive) according to different clinical types of HBV infected. The HBV-DNA load in serum, saliva and milk HBV-DNA of women were compared among the three groups, and the correlation was analyzed. Results: The positive rates of HBsAg and HBV-DNA in serum, saliva and milk of the puerpera in group A were the highest (P<0.001). There were no significant different in the positive rates of HBsAg and HBV-DNA in serum and saliva of the puerpera between group B and C (P>0.05), but the positive rates of HBsAg and HBV-DNA in milk was significant lower than those in serum and saliva (P<0.001). The proportion of HBV-DNA load≥1.0×109 in the serum, saliva and milk of the puerpera in group A was significant higher than that of puerpera in group B and C (P<0.05). The proportion of HBV-DNA load <1.0×105 in the breast milk of puerpera in group B and C was significant higher than that in the saliva and serum (P<0.05). The positive rate of HBV-DNA in saliva and milk of puerpera with HBV infection was positive correlated with the HBV-DNA load in the serum (P<0.001). Conclusion: The HBV in saliva and milk of the puerpera with HBV infection has infectious, especially for the puerpera with HBsAg, HBeAg and Anti-HBc positive, and the infectious of HBV in saliva is more than that in milk.
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