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| Clinical significance of the levels of serum homocysteine, folic acid, and vitamin B12 for diagnosing hypertensive disorder complicating pregnancy |
| Tongren Municipal People's Hospital, Guizhou Province，554300 |
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Abstract To explore the clinical value of serum homocysteine (Hcy), folic acid, and vitamin B12 for diagnosing hypertensive disorder complicating pregnancy. Methods: The data of 143 pregnant women with hypertensive disorder complicating pregnancy from April 2017 to October 2019 were analyzed retrospectively, which included 50 cases in group A (pregnant women with pregnancy-induced hypertension), 48 cases in group B (pregnant women with mild preeclampsia), and 45 cases in group C (pregnant women with severe preeclampsia). During the same time, 40 healthy pregnant women were selected in group D and 35 healthy non-pregnant women were selected in group E. The levels of serum Hcy, folic acid, and vitamin B12 of the women in the five groups were detected and compared. Receiver operating characteristic curve (ROC) was used to analyze the efficacy of the levels of serum Hcy, folic acid, and vitamin B12 for diagnosing hypertensive disorder complicating pregnancy. Logistic regression analysis was used to analyze the risk factors of pregnancy outcomes of pregnant women. Results: The Hcy level of pregnant women in group A, B, and C had increased in turn significantly, which was significant higher than that of women in group D or in group E. The folic acid and vitamins B12 levels of pregnant women in group A, B, and C had decreased in turn significantly, which were significant lower than those of women in group D or in group E (P＜0.05). The Hcy was negatively correlated with the levels of folic acid and vitamin B12 (P＜0.05), the folic acid level was positively correlated with the vitamin B12 level (P＜0.05). The levels of serum Hcy, folic acid, and vitamin B12 could be used to diagnose hypertensive disorder complicating pregnancy, and the diagnostic efficiency of the combination of the serum Hcy level, folic acid level, and vitamin B12 was the highest (P＜0.05). The serum Hcy level of women with normal pregnancy outcomes was significant higher than that of women with adverse pregnancy outcomes, but the levels of folic acid and vitamin B12 of women with normal pregnancy outcomes were significant lower (P＜0.05). Hcy, folic acid and vitamin B12 levels were independent influencing factors of adverse pregnancy outcomes of pregnant women with hypertensive disease during pregnancy (P＜0.05). Conclusion: The diagnostic efficiency of the combination of the serum Hcy, folic acid and vitamin B12 levels is higher than that of the serum Hcy level, folic acid level, or vitamin B12 level only. High serum Hcy level and low folic acid and vitamin B12 levels of women with hypertensive disorder complicating pregnancy indicate adverse pregnancy outcomes.
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