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| Value of color Doppler ultrasound combined with maternal plasma free placental RNA level for diagnosing of placental implantation |
| The First People's Hospital of Foshan, Guangdong Province, 528000 |
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Abstract To explore the value of color Doppler ultrasound combined with the mRNA of maternal plasma free placenta human placenta prolactin (HPL),β-Human chorionic gonadotropin subunit (β-hCG), tissue factor pathway inhibitor 2 (TFPI2) for diagnosing pregnant women with placental implantation. Methods: 131 pregnant women who had been suspected placental implantation were selected as the study subjects. According to the pathological diagnosis after delivery, these women were divided into study group (45 women with placenta implantation) and control group (86 women without placenta implantation). All women had been examined by transabdominal color Doppler ultrasound. The expression of HPL mRNA,β-hCG mRNA and TFPI2 mRNA in maternal plasma were detected by real-time quantitative PCR. The value of different methods for diagnosing placental implantation was analyzed based on the last pathological results. Results: 32 women with placenta implantation were diagnosed by color Doppler ultrasound. The sensitivity and the specificity of color Doppler ultrasound for diagnosing placenta implantation were 71.1% and 87.2%, respectively. The expression of HPL mRNA, β-hCG mRNA and TFPI2 mRNA of women in the study group were significant higher than those of women in the control group (P＜0.05). ROC analysis showed that the AUC of HPL mRNA, β-hCG mRNA and TFPI2 mRNA for diagnosing placenta implantation were 0.634, 0.582 and 0.639, respectively. The sensitivity, the specificity, the positive predictive value, and the negative predictive value of ultrasound combined with the HPL mRNA expression,β-hCG mRNA expression, and TFPI2 mRNA expression for diagnosing placental implantation were 89.7%, 93.2%, 92.2%, and 95.6%, respectively, which were all significant higher than those of ultrasound, the HPL mRNA expression,β-hCG mRNA expression, or TFPI2 mRNA expression single diagnosis only. Conclusion: Color Doppler ultrasound combined with maternal plasma free placenta mRNA level detection can increase the value for diagnosing prenatal placenta implantation.
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