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Abstract To explore the clinical effect of spinal anesthesia combined with intermittent epidural bolus (IEB) for treating women during maternal labor analgesia. Methods: 600 pregnant women with full term pregnancy were randomly divided into observation group and control group (300 cases in each group) by random number table from January 2014 to May 2019. The women in the control group were treated with IEB, and the women in the observation group were treated with spinal anesthesia combined with IEB. The analgesic effect, the indexes during and after operation, the situation of motor block, and the levels of T lymphocyte subsets， and inflammatory factors after delivery of women were compared between the two groups. Results: The VAS scores of women in the observation group 2h after anesthesia and during delivery were significant lower than those of women in the control group (P＜0.05). There were no significant different in the time of labor, the time of analgesia, the time of and duration of interval uterine contraction, the fetal heart rate, the adverse reactions rate, and neonatal Apgar scores between the two groups (P＞0.05). The rates of patient control epidural analgesia given, the oxytocin used, cesarean section, and motor block of women in the observation group were significant lower than those of women in the control group, but the satisfaction score of women in the observation group was significant higher (P＜0.05). 24h after delivery, the levels of CD3+, CD4+, CD4+/CD8+ of women in the observation group were significant higher than those of women in the control group (P＜0.05), but the levels of IL-6 and TNF-α during delivery and 24h after delivery of women in the observation group were significant lower (P＜0.05). Conclusion: IEB used in labor analgesia has better effect with less dosage of anesthetic drugs, and the satisfaction of women is high, which is helpful to reduce the rates of cesarean section and motor block, and can improve the immune suppression and inflammatory response of women.
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