Abstract To investigate the clinical effect of different ovarian stimulation regimen for treating different age women with poor ovarian response (POR) assisted by in vitro fertilization-embryo transfer (IVF-ET). Methods: 336 cycles of women with POR who received IVF-ET were selected in this study from August 2016 to August 2019. They were divided into group A (age <35 years old, long-term regimen during early follicular phase, 75 cycles), group B (age <35 years old, antagonist regimen, 81 cycles) and group C (age ≥35 years old, long-term regimen during early follicular phase, 87 cycles), and group D (age ≥35 years old, antagonist regimen, 93 cycles). The clinical indicators and outcomes of women were compared among the four groups. Results: The total dosage of Gn, duration of Gn used, the endometrial thickness on the hCG day, the rates of fertilization, the available embryo number, the embryo implantation rate, and the pregnancy rate of women in group A were significant higher than those of women in group B, but the levels of estradiol (E2), luteinizing hormone (LH) and progesterone (P) on hCG day of women in group A were significant lower (all P＜0.05). There were no significant difference in the rates of cancellation, high quality embryo, abortion, multiple pregnancy, ectopic pregnancy, and preterm birth, and neonatal weight of women between group A and B (P＞0.05). The total dosage of Gn, duration of Gn used, the endometrial thickness on the hCG day, and the rates of the embryo implantation and pregnancy of women in group C were significant higher than those of women in group D, but the levels of E2, LH and P on the hCG day of women in group C were significantly lower (P＜0.05). There were no significant difference in the rates of cycle cancellation, fertilization, available embryo, high quality embryo, abortion, multiple pregnancy, ectopic pregnancy, and preterm birth, and neonatal weight of women between group C and D (P＞0.05). Conclusion: Application of long protocol during early follicular phase can effectively improve the clinical outcomes of different age women with POR assisted by IVF-ET, which has good clinical application value, but it will increase the total dosage and time of Gn used, and it will increase the cost.
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