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| Pregnancy outcomes of triptorelin acetate, gestrinone and mifepristone tablets for treating infertile women with endometriosis |
| 1. General Hospital of the Central Theater Command, PLA, Wuhan, Hubei Province, 430070; 2. Hubei Maternal and Child Health Care Hospital |
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Abstract To compare the pregnancy outcomes of triptorelin acetate, gestrinone and mifepristone tablets for treating infertile women with endometriosis (EMT). Methods: 132 infertility women with EMT were enrolled and had received laparoscopic conservative operation from May 2012 to July 2017. After operation, these women were divided into group A group (42 women treated by triptorelin acetate), group B (45 women treated by 45 gestrinone tablets cases), and group C (45 women treated by mifepristone tablets). The clinical efficacy, pain degree by VAS, sex hormones levels, pregnancy outcomes, and adverse reaction rate were compared among these three groups. Results: After treatment, the total effective rate of women in group A was 97.6%, followed was that (88.9%) of women in group C, and that (73.3%) of women in group B (P＜0.05). The levels of FSH, PRL and E2, the dysmenorrheal rate, and sexual intercourse, and VAS score of pelvic pain of women in the three groups had decreased significantly after treatment, but LH level had increased. The levels of FSH, PRL and E2 of women in group A and group C were significant lower than those of women in group B, but the LH level of women in group A and group C was significant higher. The dysmenorrheal rate, the sexual intercourse score, or VAS score of pelvic pain of women in group B was the highest. The rate of good pregnancy outcomes of women in group A was 90.5%, then was that (62.2%) of women in group C, and that (42.2%) of women in group B was the lowest. The incidence of adverse reaction of women in group A was 7.1%, followed by that (33.3%) of women in group C, and then that (40.0%) of women in group B (all P＜0.05). Conclusion: Laparoscopic surgery combined with triptorelin acetate for treating infertile women with EMT has the best curative effect, which can improve the pregnancy rate, and has better pregnancy outcomes and less adverse reaction.
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