To explore the value of the levels of serum interacting protein 1 (LRRFIP1), placental growth factor (PLGF), and soluble Fms-like tyrosine kinase-1 (sFlt-1) for diagnosing and prognosis evaluation of elderly women with pregnancy-induced hypertension. Methods: 61 elderly women with pregnancy-induced hypertension were selected in observation group, which included 26 women with mild pregnancy-induced hypertension in group A, 25 women with mild preeclampsia in group B, and 10 women with severe preeclampsia in group C. Another 50 normal pregnant women were selected in control group. The levels of serum LRRFIP1, PLGF and sFlt-1 of all included women were detected, and the ratio of sFlt-1 to PLGF was calculated. All women were followed up until the termination of pregnancy. The differences of the levels of serum LRRFIP1, sFlt-1, and PLGF, and sFlt-1/PLGF value of women with different illness degree and with different pregnancy outcomes were observed. ROC analysis was used to explore the value of the levels of serum LRRFIP1, sFlt-1, and PLGF, and sFlt-1/PLGF value for diagnosing pregnancy-induced hypertension of elderly pregnant women and predicting their prognosis. Results: The serum PLGF level of women in the observation group was significant lower than that of women in the control group (P<0.05). The PLGF level had decreased with the aggravation of pregnancy-induced hypertension, but the levels of serum LRRFIP1 and sFlt-1, and PLG, and sFlt-1/PLGF value had increased with the aggravation of pregnancy-induced hypertension. The PLGF level of women with adverse pregnancy outcomes was significant lower than that of women with normal pregnancy outcomes, but the levels of serum LRRFIP1 and sFlt-1, and PLG, and sFlt-1/PLGF value of women with adverse pregnancy outcomes was significant higher (all P<0.05). The area under curve (AUC) of sFlt-1/PLGF ratio for diagnosing pregnancy-induced hypertension and predicting adverse pregnancy outcomes were 0.922 and 0.937, which were significant higher than those (0.901 and 0.891) of the levels of sFlt-1, PLGF, and LRRFIP1. Conclusion: The serum LRRFIP1 level and sFlt-1/PLGF value of elderly women with pregnancy-induced hypertension has significantly increased, and they are closely related to the severity and prognosis of the disease, which can be used as the auxiliary indexes for diagnosing and predicting pregnancy outcomes of elderly women with pregnancy-induced hypertension.

Effect of different treatments of cervical lesions of pregnant women on their pregnancy outcomes and delivery mode[J]. 中国计划生育学杂志, 2020, 28(7): 1108-1113.