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Abstract To explore the relationships between serum micro RNA-34a (miR-34a) and micro RNA-200a (miR-200a) levels of women with gestational diabetes mellitus (GDM) and their insulin resistance. Methods: The clinical data of pregnant women from April 2015 to December 2016 were collected. According to the results of oral glucose tolerance test (OGTT) of these women, 90 women with GDM diagnosed in the 24-32th gestational weeks were included in group A, and 60 pregnant women with normal glucose tolerance (NGT) were in group B during the same period. The age, gestational weeks, body mass index (BMI) of women when included this study in both groups were analyzed. The levels of serum miR-200a, miR-34a, OGTT (blood sugar value in different time point), fasting blood glucose (FPG), fasting insulin (FINS) of women in both groups were measured, and their insulin resistance index (HOMA-IR) was calculated. Results: There were no significant different in age, gestational weeks, BMI value, and diabetes history of women between the two groups (P>0.05). The levels of serum miR-200a and miR-34a of women in group A were significant higher than those of women in group B, and the levels of 1h PG, 2hPG, FPG, FINS and HOMA-IR value of women in group A were significant higher (all P<0.05). The multiple regression equation analysis showed that the levels of serum miR-34a, miR-200a, 1hPG and 2hPG of patients with GDM were closely related to their value of HOMA-IR (P<0.05). Pearson correlation analysis showed that HOMA-IR was positively correlated with the levels of miR-34a and miR-200a. Logistic regression analysis showed that the levels of miR-34a and miR-200a, and HOMA-IR value were the influencing factors of GDM occurrence. Conclusion: Serum miR-34a and miR-200a levels of patients with GDM has up-regulated, which are positively correlated with HOMA-IR value, and the serum miR-34a and miR-200a levels, and HOMA-IR value are risk factors of GDM.
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