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| Relationship between the pregnancy outcomes of women with PCOS after IVF-ET and their levels of serum estrogen, TPO-Ab, TG-Ab and AMH |
| The Second People's Hospital of Yunnan Province, Kunming, Yunnan Province, 650021 |
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Abstract To analyze relationship between the pregnancy outcomes of women with polycystic ovary syndrome (PCOS) after in vitro fertilization-embryo transfer (IVF-ET) and their levels of serum estrogen (E2), thyroid peroxidase antibody (TPO-Ab), thyroglobulin antibody (TG-Ab), and anti-Mullerian Hormone (AMH). Methods: The clinical data of 360 women with PCOS who underwent IVF-ET were analyzed retrospectively. According to different E2 level on the human chorionic gonadotropin (HCG) day, these women were divided into group A1 (women with low E2 level), group A2 (women with middle E2 level), and group A3 (women with high E2 level). According to the detection results of TPO-Ab and TG-Ab, these women were divided into group B1 (women with positive thyroid autoantibody) and group B2 (women with negative thyroid autoantibody). And according to serum AMH level, these women were divided into group C1 (women with high AMH level), group C2 (women with middle AMH level), and group C3 (women with low AMH level). The pregnancy outcomes were compared among these groups. Results: The fertilization rate and clinical pregnancy rate of women in group A2 were 81.7% and 56.9%, which were significant higher than those of women in group A1 and A3 (P<0.05), but which had no significant different between group A1 and A3 (P>0.05). The fertilization rate of women in group B1 was 72.5%, which was significant lower than that (79.7%) of women in group B2, but early abortion rate of women in group B1 was 39.5%, which was significant higher than that (17.2%) of women in group B2 (P<0.05). The numbers of transplanted embryos and highquality embryos of women in group C3 were 1.43±0.20 pieces and 3.07±0.60 pieces, which were significant less than those (1.86±0.24 pieces and 4.25±0.71 pieces) of women in group C2, and those (2.45±0.25 pieces and 7.52±1.02 pieces) of women in group C1 were the highest (P<0.05). Conclusion: Reasonable controlling serum E2 level of women with PCOS after IVF-ET can increase the fertilization rate and clinical pregnancy rate. The positive thyroid autoantibody of women with PCOS can increase their early abortion risk. The number of transplanted embryos and high-quality embryos of women with high AMH level is more, which can provide conditions for better pregnancy outcomes.
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