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| Correlation between Sigma-1 receptor and degenerative of infertile patients with low ovarian reserve |
| 1. General Hospital of Zhengzhou Coal Industry (Group) Co., Ltd., Henan Province；2. Henan Provincial People's Hospital |
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Abstract To investigate the correlation between Sigma-1 receptor and degenerative of infertile patients with low ovarian reserve. Methods: 80 infertile women were enrolled in the study from January 2016 to December 2018. According to the ovarian reserve function, 47 patients with low ovarian reserve were included in observation group, and 33 patients with normal ovarian reserve were included in control group. The expression levels of Sigma-1 receptor protein in plasma, follicular fluid, and granular cell were compared between the two groups and the correlation of them were analyzed. Results: The levels of basal follicular generation hormone (FSH), age of patients in the observation group were significant higher than those of patients in the control group, but the levels of anti-Mulller's hormone (AMH), basal antral follicular count (AFC), the acquired eggs, available embryos, and expression of plasma Sigma-1 receptor protein, follicular fluid, and granular cell of patients in the observation group were significant lower than those of patients in the control group (P<0.05). In the observation group, the expression of Sigma-1 receptor protein in granular cells and plasmaand follicular fluid was negative correlated with basal FSH level and age of patients, and was positive correlated with AMH level, AFC, number of eggs obtained, and number of available embryos (P<0.05). Conclusion: Sigma-1 receptor maybe participate in the regulation of ovarian reserve function, which’s low expression is associated with the low ovarian reserve, so it is suggests that Sigma-1 receptor may be used as a potential clinical marker for predicting ovarian reserve.
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