To investigate the effect of low abdominal aortic extravascular occlusion for treating pregnant women with placenta previa, and to study its influence on their stress response index, pigment epithelium derived factor (PEDF) level, and vascular endothelial growth factor (VEGF) level . Methods: 98 pregnant women with placenta previa were randomly divided into two groups (49 cases in each group) from January 2017 to January 2019. The women in the control group had received the routine precautionary measures for bleeding, such as uterine artery ligation, gauze packing, water sac compression, oxytocin treatment after the operation, while the women in the observation group had received the low abdominal aortic extravascular occlusion for preventing bleeding. Relevant intraoperative indicators, stress response indicators, PEGF and VEGF levels, neonatal Apgar score, and complications of women were compared between the two groups. Results: The blood loss, blood transfusion volume, total operation time, hospitalization time, and operation time of women in the observation group were significant lower than those of women in the control group, but Apgar scores of newborn 1 min, 5 min and 10 min after birth in the observation group were significant higher than those of newborn in the control group (P<0.05). After operation,the PEPF level of women in the observation group was significant higher than that of women in the control group, but the levels of VEGF, NE and ADS of women were significant lower (P<0.05). The incidence of complications of women in the observation group was 16.3％, which was significant lower than that (34.7％) of women in the control group (P<0.05). Conclusion: Low abdominal aortic extravascular occlusion for treating pregnant women with placenta previa can effectively improve operation related indicators, improve neonatal Apgar score, reduce stress response, up-regulate PEGF index and inhibit VEGF level, and reduce adverse reactions.