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Abstract To study the effect of gongliuxiao capsules combined with danazol capsules on the related factors of patients with endometriosis. Methods: 110 patients with endometriosis were enrolled in this study and were randomly divided into control group and treatment group (55 cases in each group) from January 2017 to December 2018. The patients in the control group were treated with danazol capsules for 3 months, and the patients in the treatment group were treated with gongliuxiao capsules combined with danazol capsules for 3 months. The serum PGE2, TNF-α, IL-1β, MMP-2, MMP-9, CA125, CA199, VEGF, Ang -2, MMIF, MDA, SOD of patients in the two groups before and after treatment were detected and compared. Results: After treatment, the serum PGE2 and SOD levels of patients in the two groups had significantly increased, but the serum levels of TNF-α, IL-1β, MMP-2, MMP-9, CA125, CA199, VEGF, Ang-2, MMIF, and MDA had significantly decreased (P<0.05), and the change of those levels of patients in the treatment group was significant more than those of patients in the control group (P<0.05). Conclusion: Gongliuxiao capsules combined with danazol capsules can reduce the serum levels of inflammatory cytokines of patients with endometriosis, which can help to improve the vascular endothelial function and reduce the oxidative stress reaction of patients.
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