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| Effect of Shugan jianpi pecipe combined with insulin pump for treating women with gestational diabetes mellitus because of liver stagnation and spleen deficiency on their blood lipid metabolism, pregnancy outcomes, and TLR4 classical signaling pathway of peripheral blood mononuclear cells |
| 1. Xinle City Hospital of Hebei Province, Hebei Province, 050700; 2. Gaocheng People's Hospital of Shijiazhuang City; 3. The Second Hospital of Bazhou |
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Abstract To investigate the effect of Shugan jianpi pecipe combined with insulin pump for treating women with gestational diabetes mellitus (GDM) because of liver stagnation and spleen deficiency on their blood lipid metabolism, pregnancy outcomes, and TLR4 classical signaling pathway of peripheral blood mononuclear cells. Methods: According to the randomized double-blind method, 100 pregnant women with GDM because of liver stagnation and spleen deficiency were divided into control group and study group (50 cases in each group) from October 2017 to February 2019. The women in the control group were treated with continuous subcutaneous injection of insulin pump, and the women in the study group were treated with Shugan jianpi pecipe combined with injection of insulin pump. The blood glucose and lipid metabolism, TCM syndrome scores, pregnancy outcomes, neonatal complications rate, and TLR4 gene expression were compared between the two groups. Results: The levels of FPG, 2hPBG, HbA1c, total cholesterol, triglyceride, TCM syndrome scores, mRNA and protein expression of TLR4 gene of women in the study group were significant lower than those of women in the control group (P<0.05). The incidences of cesarean section and abortion of women in the study group were 20.0% and 2.0%, which were significant lower than those (38.0% and 14.0%) of women in the control group (P<0.05). There were no significant different in the incidences of oligohydramnios, premature rupture of membranes, and pregnancy-induced hypertension between the two groups (P>0.05). The total incidence of neonatal complications in the study group was 14.0%, which was significant lower than that (32.0%) in the control group (P<0.05). Conclusion: Shugan jianpi pecipe combined with insulin pump for treating women with GDM because of liver stagnation and spleen deficiency can effectively decrease blood lipid level, improve pregnancy outcomes, and inhibit the expression of TLR4 in peripheral blood mononuclear cells.
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