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| Changes of serum IL-18 and CCL-1 levels of pregnant women with group B Streptococcus positive during the third trimester of pregnancy, and their value for predicting the pregnancy outcomes |
| The Ninth People's Hospital of Shanghai, Shanghai, 200083 |
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Abstract To investigate the changes of serum interleukin-18 (IL-18) and chemotactic cytokine ligand-1 (CCL-1) levels of pregnant women with group B Streptococcus (GBS) positive during the third trimester of pregnancy, and to analyze their value for predicting the pregnancy outcomes. Methods: From September 2017 to July 2019, 70 pregnant women with GBS positive during the third trimester of pregnancy were selected in study group, which included 20 GBS carrier, 42 women with GBS subclinical infection, and 8 women with GBS chorioamnionitis. 60 normal pregnant women during the third trimester pregnancy were selected in control group during the same period. The levels of serum IL-18 and CCL-1 of all women were detected by enzyme-linked immunosorbent assay (ELISA). Logistic regression analysis was used to analyze the factors for influencing the adverse pregnancy outcomes of women with GBS positive during the third trimester of pregnancy, and ROC curve was used to analyze the predictive values of serum IL-18 and CCL-1 for adverse pregnancy outcomes of women with GBS positive during the third trimester of pregnancy. Results: The levels of serum IL-18 and CCL-1 of women in study group were significant higher than those of women in the control group, and those of women with amniotic membrane inflammation were highest. The incidences of intrauterine infection, fetal distress, premature delivery, and amniotic fluid pollution of women in the study group were significant higher than those of women in the control group (all P<0.05). The logistic regression analysis showed that levels of IL-18 and CCL-1 were the risk factors for adverse pregnancy outcomes of women with GBS positive during the third trimester pregnancy. ROC curve analysis showed that the areas under curve of IL-18 level, CCL-1 level, and IL-18 level combined with CCL-1 level for predicting the adverse pregnancy outcomes of women with GBS positive during the third trimester of pregnancy were 0.860, 0.762 and 0.925, respectively, their sensitivity were 70.0%, 70.0%, 93.3%, respectively, and their specificity were 85.0%, 73.3% and 98%, respectively. Conclusion: The levels of serum IL-18 and CCL-1 of pregnant women with GBS positive during the third trimester of pregnancy increase, which is related to adverse pregnancy outcomes, so both the levels of serum IL-18 and CCL-1 may be used as indicators to judge GBS infection status and to predict pregnancy outcomes.
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